Open AccessThe lncRNA PVT1/miR-423-5p axis is positively correlated with the severity of bronchial asthma
Author(s) -
Ju Qiu,
Kai Zhang,
Jing Liu,
Dianfeng Cao,
Ping Gao,
Baoling Zhang,
Na Zhao,
Ruofang Wang,
Xinsheng Shi
Publication year - 2022
Publication title -
allergologia et immunopathologia
Language(s) - English
Resource type - Journals
eISSN - 1578-1267
pISSN - 0301-0546
DOI - 10.15586/aei.v50i1.472
Subject(s) - pvt1 , medicine , exacerbation , gastroenterology , asthma , asthma exacerbations , receiver operating characteristic , downregulation and upregulation , long non coding rna , biology , biochemistry , gene
Bronchial asthma (BA) is a serious problem affecting the quality of life of patients. Long non-coding RNAs (lncRNAs) are involved in BA. This study set out to investigate expressions of PVT1/miR-423-5p in the serum of BA patients and its clinical value on BA diagnosis and evaluation. This study included the same number (N = 100) of patients with BA at remission (BA-R), BA at exacerbation (BA-E), and healthy controls. PVT1 level was increased in BA-R and BA-E patients, and PVT1 level was higher in BA-E patients than BA-R patients. miR-141-3p targeted PVT1. miR-423-5p was downregulated in the serum of BA patients and was negatively correlated with PVT1. Area under ROC curve of PVT1/miR-423-5p axis on BA-R patients was 0.837 with sensitivity 0.74, specificity 0.84, while that of BA-E was 0.974 with sensitivity 0.87 and specificity 0.95. PVT1/miR-423-5p axis was negatively correlated with FEV1/FVC, FEV1% pred, and IL-10, and positively correlated with IgE, TNF-α, and IL-6. PVT1 and PVT1/miR-423-5p axis were associated with increased severity while miR-423-5p axis was negatively associated with BA severity. In conclusion, increased levels of PVT1/miR-423-5p had higher diagnostic efficiency on BA patients, especially patients with acute exacerbation.