Study on the molecular mechanism of Guizhi Jia Shaoyao decoction for the treatment of knee osteoarthritis by utilizing network pharmacology and molecular docking technology | Zendy

Pin Deng | Zendy; Huan Liang | Zendy; Kunming Xie | Zendy; Jinglu Han | Zendy; Fasen Huang | Zendy; Huanyu Liu | Zendy; Hanjie Zhu | Zendy; Zhichao Huang | Zendy; Qiong Wu | Zendy; Jingwei Tao | Zendy; Lan Li | Zendy; Zhaojun Chen | Zendy

Open Access

Study on the molecular mechanism of Guizhi Jia Shaoyao decoction for the treatment of knee osteoarthritis by utilizing network pharmacology and molecular docking technology

Author(s) -

Pin Deng,

Huan Liang,

Kunming Xie,

Jinglu Han,

Fasen Huang,

Huanyu Liu,

Hanjie Zhu,

Zhichao Huang,

Qiong Wu,

Jingwei Tao,

Lan Li,

Zhaojun Chen

Publication year - 2021

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v49i6.484

Subject(s) - drugbank , systems pharmacology , medicine , kegg , computational biology , docking (animal) , pharmacology , interaction network , baicalin , bioinformatics , gene ontology , gene , gene expression , biology , biochemistry , drug , nursing , chemistry , high performance liquid chromatography , chromatography

Guizhi Jia Shaoyao decoction (GSD) is widely used in the clinical treatment of knee osteoarthritis (KOA). However, the underlying molecular mechanisms remain unclear. The aim of this study was to explore functional mechanisms of GSD in treating KOA by utilizing network pharmacology-based approaches.

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