SEMA3A protects against hyperoxia-induced lung injury in a bronchopulmonary dysplasia model of newborn rat by inhibiting ERK pathway | Zendy

Zhenyu Liang | Zendy; Xiao Zhang | Zendy; Yingxian Liu | Zendy; Qianmei Wu | Zendy; Chuming You | Zendy

Open Access

SEMA3A protects against hyperoxia-induced lung injury in a bronchopulmonary dysplasia model of newborn rat by inhibiting ERK pathway

Author(s) -

Zhenyu Liang,

Xiao Zhang,

Yingxian Liu,

Qianmei Wu,

Chuming You

Publication year - 2021

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v49i6.478

Subject(s) - hyperoxia , bronchopulmonary dysplasia , medicine , lung , pathology , cancer research , immunology , biology , pregnancy , genetics , gestational age

Hyperoxia induces lung injury through lung inflammation in premature infants, leading to bronchopulmonary dysplasia (BPD). Semaphorin 3A (SEMA3A) participates in diverse biological processes, including cell migration, angiogenesis, and inflammation. The effect of SEMA3A on hyperoxic lung injury of neonatal rats with BPD was investigated in this study.

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