Open AccessClinical features of children with atopic dermatitis according to filaggrin gene variants
Author(s) -
Arghavan Ziaali,
Laleh Sharifi,
Shahram Teimourian,
Bita Hasani,
Anna Isaian,
Mansoureh Shariat
Publication year - 2021
Publication title -
allergologia et immunopathologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 37
eISSN - 1578-1267
pISSN - 0301-0546
DOI - 10.15586/aei.v49i4.209
Subject(s) - medicine , atopic dermatitis , filaggrin , dermatology
Filament aggregating protein (Filaggrin) is a skeletal cell component that provides a protective function for the epidermis. Mutations of the filaggrin gene ( FLG ) cause a loss of filaggrin protein. These mutations are seen in 50% of atopic dermatitis (AD). The aim of the study was to investigate the polymorphisms and mutations of the FLG in Iranian children with AD.
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