Open AccessHospital admission for symptoms exacerbation in 2,075 infants suffering from recurrent asthma-like symptoms (EISL-3 South America)
Author(s) -
Javier Mallol,
Dírceu Solé,
Carolina Sánchez Aranda,
Eliana Toledo,
Viviana Aguirre,
Marilyn Urrutia-Pereira,
Gabriela Szulman,
Nelson Rosário,
Herberto Chong,
Líllian Sanchez-Lacerda,
Jürg Niederbacher,
Catalina Pinchak,
Patricia Polles de Olivera,
Erika Arruda-Chávez,
Luis GarcíaMarcos
Publication year - 2021
Publication title -
allergologia et immunopathologia
Language(s) - English
Resource type - Journals
eISSN - 1578-1267
pISSN - 0301-0546
DOI - 10.15586/aei.v49i4.100
Subject(s) - medicine , asthma , pediatrics , exacerbation , logistic regression
Background: Contrary to what happens in children and adults, the prevalence and the factors related to hospitalisation for asthma/wheezing in infants with recurrent asthma-like symptoms are poorly known.Methods: This study is part of the International Study of Wheezing in infants Phase 3; 2,079 infants (aged 12–18 months) with recurrent asthma-like symptoms, from 11 South American centres, were studied to determine the prevalence and the associated factors for wheezing exacerbation admission. Descriptive statistics and multivariate logistic regression were employed for analysis.Results: The prevalence of admission for wheezing was 29.7% (95% CI 27.7–31.6) and was significantly associated to severe wheezing episodes (OR: 3.89; 95% CI: 2.93–5.18, p 12 years) (OR: 0.66; 95% CI: 0.51–0.85, p = 0.001) and total monthly household income ≥US$ 3,000 (OR: 0.34; 95% CI: 0.18–0.67, p = 0.002), were protective factors.Conclusions: Infants with recurrent asthma-like symptoms have a high rate of admissions. Tobacco smoking in pregnancy, viral respiratory illness in the first trimester of life and severe progression were risks for admissions. Improving medical management to prevent severe exacerbations, prolonging the postnatal period at home longer than 3 months, favouring breastfeeding and avoiding smoking during pregnancy may have a preventive role for admissions in infants with recurrent asthma-like symptoms.