Open AccessChitosan nanoparticles: process and their application as drug delivery.
Author(s) -
Hari Eko Irianto,
Ijah Muljanah
Publication year - 2010
Publication title -
squalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 1
eISSN - 2406-9272
pISSN - 2089-5690
DOI - 10.15578/squalen.v6i1.55
Subject(s) - chitosan , drug delivery , nanoparticle , emulsion , nanotechnology , biocompatible material , drug carrier , gene delivery , materials science , drug , chemical engineering , chemistry , organic chemistry , biomedical engineering , pharmacology , genetic enhancement , medicine , biochemistry , engineering , gene
Chitosan has wide ranges of potential applications and Indonesia possesses abundant rawmaterial sources such as crab and shrimp shells to produce it. Chitosan have beneficial properties,i.e. biocompatible, biodegradable, non-toxic and inexpensive. Nowadays, several experimentson the preparation of chitosan into nanoparticles and its utilization as drug delivery for varioustargeted therapies have been conducted. Chitosan nanoparticles can be prepared using variousmethods, e.g. emulsion cross-linking, precipitation, spray drying, emulsion-droplet coalescencemethod, ionic gelation, reverse micellar method and polyelectrolyte complex. Applications ofchitosan nanoparticles as drug delivery can be performed through diverse administrations includingparenteral, peroral and ocular, non-viral gene delivery vectors, vaccine delivery, and photodynamictherapy.