Open AccessPiezoelectric bioMEMS cantilever for measurement of muscle contraction and for actuation of mechanosensitive cells
Author(s) -
Elizabeth A. Coln,
Alisha Colón,
Christopher J. Long,
Narasimhan Narasimhan Sriram,
Mandy B. Esch,
JeanMatthieu Prot,
Daniel Elbrecht,
Ying I. Wang,
Max Jackson,
Michael L. Shuler,
James J. Hickman
Publication year - 2019
Publication title -
mrs communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.751
H-Index - 31
eISSN - 2159-6859
pISSN - 2159-6867
DOI - 10.1557/mrc.2019.129
Subject(s) - cantilever , materials science , piezoelectricity , actuator , microelectromechanical systems , pmut , piezoelectric sensor , optoelectronics , mechanosensitive channels , biomedical engineering , nanotechnology , acoustics , composite material , electrical engineering , physics , engineering , medicine , biochemistry , chemistry , receptor , ion channel
A piezoelectric biomedical microelectromechanical system (bioMEMS) cantilever device was designed and fabricated to act as either a sensing element for muscle tissue contraction or as an actuator to apply mechanical force to cells. The sensing ability of the piezoelectric cantilevers was shown by monitoring the electrical signal generated from the piezoelectric aluminum nitride in response to the contraction of iPSC-derived cardiomyocytes cultured on the piezoelectric cantilevers. Actuation was demonstrated by applying electrical pulses to the piezoelectric cantilever and observing bending via an optical detection method. This piezoelectric cantilever device was designed to be incorporated into body-on-a-chip systems.