Open AccessTherapeutic Potential of CXCR4/SDF-1 Axis in Acute Myocardial Infarction
Author(s) -
Shirin Toosi,
Javad Behravan,
Asieh HeiraniTabasi
Publication year - 2017
Publication title -
journal of genes and cells
Language(s) - English
Resource type - Journals
ISSN - 2410-6887
DOI - 10.15562/gnc.52
Subject(s) - homing (biology) , cxcr4 , stem cell , mesenchymal stem cell , myocardial infarction , medicine , stem cell therapy , haematopoiesis , immune system , cell therapy , immunology , cancer research , cardiology , biology , pathology , microbiology and biotechnology , chemokine , ecology
Acute Myocardial Infarction (AMI) is one of the mortal diseases which relate to heart and has many impacts on patients’ life. Stem cell therapy, including mesenchymal stem cells (MSCs), has emerged a promise treatment for patients with this disease. However, the inefficient migration and homing of MSCs have limited their therapeutic applications. It has been demonstrated that CXCR4/SDF-1 axis has a crucial role in cell migration and stem cell homing. So, many studies have conducted and currently are operating by novel methods to improve homing of MSCs by up-regulating the expression of CXCR4/SDF-1 axis to discover a proper cell therapy for AMI. CXCR4/SDF-1 axis triggers a variety of biological responses, such as directing cell migration, organogenesis, hematopoiesis, vascularization, and immune responses. Therefore, this axis might be a good candidate for manipulation with therapeutic purposes.