Open AccessStem Cell Surface Markers and Their Role in Cancer Progression
Author(s) -
Samane Heidarzade,
Seyed Mohammad Amin Kormi,
Nasrin Malekpour,
Shima Ardekhani
Publication year - 2017
Publication title -
journal of genes and cells
Language(s) - English
Resource type - Journals
ISSN - 2410-6887
DOI - 10.15562/gnc.48
Subject(s) - metastasis , cancer stem cell , carcinogenesis , cancer research , cancer , stem cell , biology , tumor progression , identification (biology) , cancer cell , cell , microbiology and biotechnology , genetics , botany
Cancer progression and metastasis is rarely or less studied phenomenon. It has been known that cancer stem cells are the significant agents playing critical in metastasis and advanced tumorigenesis because of their heterogeneous nature. Their changed molecular expression with the passage of time and induction of normal cells into cancerous cells are correlated and determining these stem cell markers expression on CSCs can help to understand the progression of cancer and resistance to chemotherapy approaches. Identification of these signaling pathways and their modulation role are the key necessities for precise diagnosis and targeted therapeutic approaches development.