Curcumin a potent cancer preventive agent: Mechanisms of cancer cell killing | Zendy

Muobarak J. Tuorkey | Zendy

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Curcumin a potent cancer preventive agent: Mechanisms of cancer cell killing

Author(s) -

Muobarak J. Tuorkey

Publication year - 2014

Publication title -

interventional medicine and applied science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.195

H-Index - 14

eISSN - 2061-5094

pISSN - 2061-1617

DOI - 10.1556/imas.6.2014.4.1

Subject(s) - curcumin , cancer , epigenetics , histone , cancer cell , mechanism (biology) , wnt signaling pathway , cancer research , apoptosis , cell cycle , biology , pharmacology , signal transduction , biochemistry , dna , genetics , gene , philosophy , epistemology

There is no doubt that diet could effectively improve health and halt cancers. Dietary phytochemical compounds and their derivatives represent a cornucopia of effectively anticancer compounds. This review discusses existing data on the anticancer activities of curcumin, and then offers possible explanations for and mechanisms of its cancer-preventive action. This review also offers insights into the molecular mechanism and targets through which curcumin modulates cell cycle, apoptotic signals, anti-apoptotic proteins, miRNAs, Wnt/beta-catenin signaling, protein kinases, nuclear factor-κB, proteasome activation, epigenetic regulation including DNA methylation and histone modification. Finally, this review provides explanations for how curcumin reverses the multi-drug resistance (MDR) of cancer cells.

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