Open AccessA comparative study of vascular cell adhesion molecule-1 and high-sensitive C-reactive protein in normal and preeclamptic pregnancies
Author(s) -
Mehdi Farzadnia,
Hossein Ayatollahi,
Maliheh Hasan-Zade,
Hamid Reza Rahimi
Publication year - 2013
Publication title -
interventional medicine and applied science/interventional medicine and applied science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.195
H-Index - 14
eISSN - 2061-5094
pISSN - 2061-1617
DOI - 10.1556/imas.5.2013.1.5
Subject(s) - medicine , preeclampsia , dyslipidemia , c reactive protein , pregnancy , endocrinology , cell adhesion molecule , inflammation , immunology , obesity , genetics , biology
Background Preeclampsia is characterized by hypertension, dyslipidemia, and systemic inflammatory response. The aim of this study was to determine the level of serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1) and high-sensitive C-reactive protein (hsCRP) in preeclampsia and to compare normal pregnant, mild preeclamptic, and severe preeclamptic women. Methods A cross-sectional study was conducted to determine the plasma concentrations of sVCAM-1 and hsCRP in peripheral blood obtained from normal pregnant ( n =40), mild preeclamptic ( n =37), and severe preeclamptic women ( n =38). A concentration of soluble adhesion molecule was determined with enzymelinked immunosorbent assay. hsCRP was measured with immunoturbidometric. Results There was significant difference in the means serum hsCRP between normal pregnant women and mild preeclamptic women ( P <0.05). Serum concentration of hsCRP and sVCAM-1 (ng/mL) were significantly higher in severe preeclampsia ( P <0.05) than normal pregnancy. There were also significant differences in hsCRP and sVCAM-1 levels between mild and severe ( P <0.05). There was no difference in the mean sVCAM-1 between normal pregnant and mild preeclamptic women. Conclusion We have determined the serum concentration of VCAM-1 and hsCRP in normal pregnancy and preeclampsia. sVCAM-1 is elevated in severe preeclampsia compared with normal pregnancy, and hsCRP is elevated in severe preeclampsia compared with mild preeclampsia and normal pregnancy.