Open AccessIncreased expression of MDM2 and NM23 are associated with malignant transformation of pleomorphic adenoma
Author(s) -
Manal M. Zyada
Publication year - 2012
Publication title -
interventional medicine and applied science/interventional medicine and applied science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.195
H-Index - 14
eISSN - 2061-5094
pISSN - 2061-1617
DOI - 10.1556/imas.4.2012.1.6
Subject(s) - medicine , mdm2 , malignant transformation , adenoma , pleomorphic adenoma , pathology , immunohistochemistry , metastasis , cancer research , cancer , cell culture , biology , salivary gland , genetics
This study was designed to correlate the expression of both MDM2 and NM23 in pleomorphic adenoma (PA) to clinical background, histological features, local recurrence, and metastatic potentiality in this tumor. Expression of MDM2 and NM23 was studied immunohistochemically in 23 cases of PA. Our results demonstrated MDM2 and NM23 overexpression in almost all cases of PA. There was a significant difference of the MDM2 and NM23 mean values between benign PA and both carcinoma-ex PA and metastasizing PA. The results of this study show that the overexpression of NM23 and MDM2 oncoproteins could be used as reliable predictors of malignant progression as well as metastatic potentiality of PA.