Open AccessExpression of PTEN in basaloid squamous cell carcinoma and its clinicopathological significance
Author(s) -
Manal M. Zyada,
Nagla Salama
Publication year - 2011
Publication title -
interventional medicine and applied science/interventional medicine and applied science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.195
H-Index - 14
eISSN - 2061-5094
pISSN - 2061-1617
DOI - 10.1556/imas.3.2011.4.5
Subject(s) - pten , tensin , medicine , immunohistochemistry , tissue microarray , pathology , carcinoma , cancer research , oncology , biology , apoptosis , pi3k/akt/mtor pathway , biochemistry
There are a few ideal predictors that are used to evaluate the prognosis of basaloid squamous cell carcinoma (BSCC). This study was designed to investigate the expression of PTEN (phosphates and tensin homolog deleted on chromosome ten) and its association with clinicopathological and available follow-up data. PTEN protein was examined by using immunohistochemical SABC staining method in eight cases of BSCC. Loss of PTEN expression was noted in five (62.5%) of the eight studied BSCC cases. Statistically, there was a significant relationship between PTEN expression and studied BSCC groups depending upon the basaloid component level, lymph node involvement, and the clinical stage of the disease. Of the five patients whose tumors were PTEN negative, three (80%) had recurrence or death at follow-up, whereas none of the three patients whose tumors were PTEN positive had recurrence or death. It was concluded that the PTEN positive expression may be useful for predicting the prognosis of BSCC.