Open AccessDoxycycline pharmacokinetics in mammalian species of veterinary interest – an overview
Author(s) -
Rositsa Mileva,
Aneliya Milanova
Publication year - 2022
Publication title -
bulgarian journal of veterinary medicine
Language(s) - English
Resource type - Journals
eISSN - 1311-1477
pISSN - 1313-3543
DOI - 10.15547/bjvm.2321
Subject(s) - pharmacokinetics , doxycycline , pharmacology , pharmacodynamics , antibiotics , medicine , veterinary medicine , population , tetracycline , biology , intensive care medicine , microbiology and biotechnology , environmental health
Doxycycline is a broad-spectrum tetracycline antibiotic widely used in veterinary medicine. The current review aims to summarise the available data about pharmacokinetics in mammalian species of veterinary interest and to indicate the basic strategies for refining dosage regimens in order to use this antibiotic reasonably. Additionally, the available data about population pharmacokinetics are reviewed as this approach exhibits a number of benefits in terms of determination of drug pharmacokinetics, prediction of drug disposition and interpretation of the variations in the pharmacokinetic parameters. Further research with animal species of veterinary interest and pathogens causing diseases in animals is needed to clarify the pharmacokinetics and pharmacodynamics of doxycycline.