Open AccessBEHAVIOR OF THE PHARMACOKINETICS OF ENROFLOXACIN IN THE PHASE SPACE
Author(s) -
Miroslav Vasilev,
Galya Shivacheva
Publication year - 2019
Publication title -
applied researches in technics, technologies and education
Language(s) - English
Resource type - Journals
eISSN - 1314-8796
pISSN - 1314-8788
DOI - 10.15547/artte.2019.04.005
Subject(s) - enrofloxacin , pharmacokinetics , representation (politics) , nonlinear system , cats , phase (matter) , phase space , mathematics , plasma concentration , differential equation , computer science , biological system , antibiotics , mathematical analysis , pharmacology , chemistry , medicine , physics , thermodynamics , biology , biochemistry , organic chemistry , quantum mechanics , ciprofloxacin , politics , political science , law , embedded system
Phase space is an approach for analysis of nonlinear differential equations. The graphical solutions that are obtained are convenient for qualitative assessment of the behavior of systems and processes. A comparative analysis of the pharmacokinetics of the antibiotic enrofloxacin administered intravenously in dogs and cats has been performed in the present study. The mathematical models that represent the change in blood plasma concentration of the two groups of animals are described by second-order differential equations. For the graphical representation of phase trajectories using the fluoroquinolone, the Mathcad program tools are used. The properties of the peculiar points are determined based on the received images.