Open AccessRegulatory Innate Lymphoid Cells: A new subset of innate immune lymphocytes with more potential functions to be discovered in immune regulation
Author(s) -
Jifeng Yu,
Yingmei Li,
Weijie Cao,
Zhongxing Jiang,
Wan Dingming
Publication year - 2020
Publication title -
journal of current medical research and opinion
Language(s) - English
Resource type - Journals
eISSN - 2589-8779
pISSN - 2589-8760
DOI - 10.15520/jcmro.v3i01.251
Subject(s) - innate lymphoid cell , innate immune system , biology , immune system , immunology , inflammation , myeloid , microrna , acquired immune system , gene , genetics
Regulatory innate lymphoid cells (ILCregs) are a newly identified subset of innate immune lymphocytes. The discovery of this subset cell has revealed several inhibitory and stimulatory pathways that affect the regulatory functions of ILCregs, in addition to miRNA and other genetic molecular regulations. These pathways may play important roles in the pathogenesis and potential immunotherapy in patients with different kind of diseases, such as inflammation and ischemia / reperfusion injury of the kidney, acute myeloid leukemia, through immunomodulatory and anti-inflammatory pathway, as well as miRNA regulations. Further studies on ILCregs may be a potentially high interest in the near future.