Open AccessTo Study The Serum Vitamin –D And Oxidative Stress Status In Rheumatoid Arthritis
Author(s) -
Uma T
Publication year - 2017
Publication title -
journal of current medical research and opinion
Language(s) - English
Resource type - Journals
eISSN - 2589-8779
pISSN - 2589-8760
DOI - 10.15520/jcmro.v1i2.14
Subject(s) - rheumatoid arthritis , medicine , oxidative stress , vitamin d and neurology , thiobarbituric acid , inflammation , vitamin c , vitamin , gastroenterology , arthritis , antioxidant , endocrinology , immunology , lipid peroxidation , biochemistry , chemistry
Aim and objectives: Rheumatoid arthritis (RA) is a chronic autoimmune systemic disease characterized predominantly by synovial inflammation, leading to joint destruction. The study was undertaken to analyze the vitamin –D and oxidative stress status in Rheumatoid arthritis
Materials and methods: The Study includes Patients diagnosed as RA by using RA factor within the age group of30 to 60 years and comprised of 20 age matched control group. To assess oxidative stress, serum Malonyldialdehyde (MDA) was by thiobarbituric acid method and antioxidant level was assessed by estimation of serum vitamin C by dinitrophenyl hydrazine method. And vitamin D total is estimated by chemiluminescent immunoassay.
Results: There is a significant decreased level of vitamin -D in the RA patients (37.58±5.7ng/ml) as compared to healthy controls (58.5±5.6ngl/ml). There is a a significant increased levels of MDA in the RA patients (7.6±1.09) as compared to healthy controls (8.4±2.8). There is a significant decreased level of vitamin -c in the RA patients (0.6±0.3mg/dl) as compared to healthy controls (1.0±0.31mg/dl).
Conclusion: Low levels of Vitamin D deficiency in RA patients is associated with inflammation which leads to Increased oxidative stress status , which may lead to connective tissue degradation leading to joint and periarticular deformities in rheumatoid arthritis.