Open AccessAsymptomatic hypoglycemia among children with acute lymphoblastic leukemia on maintenance therapy
Author(s) -
Janan G. Hassan,
Ayad Mohamed
Publication year - 2019
Publication title -
innovative journal of medical and health science
Language(s) - English
Resource type - Journals
eISSN - 2589-9341
pISSN - 2277-4939
DOI - 10.15520/ijmhs.v9i1.2430
Subject(s) - medicine , asymptomatic , hypoglycemia , lymphoblastic leukemia , maintenance therapy , pediatrics , adverse effect , leukemia , chemotherapy , insulin
Background: Knowledge of the adverse effects of maintenance chemotherapy , therapy in children with acute lymphoblastic leukemia being treated according to the MRC modified protocols. Objective: To figure out the asymptomatic hypoglycemia in a sample of children patients at a stage of maintenance therapy. Methods: Prospective study was carried out over 6 months from the 1st of January 2004 till the 30th of June 2004. A total sample of 30 patients aged between (1 and 15 years) with acute lymphoblastic leukemia were included in study who were treated at Basra Maternity and child teaching hospital, all of them were being treated according to MRC modified protocol and on maintenance therapy (6 mercaptopurina + methotroxate), 35 healthy children matched for age and sex randomly selected as control. Results: Hypoglycemia were seen is 18 (60%) of patients with leukemia, 10 (55.5%) females and 8 (44.4%) males. Blood glucose level <3.33 mmol/L during 12 hours of overnight fasting. Conclusion: Hypoglycemia is the most common adverse effect in children with acute lymphoblastic leukemia on maintenance therapy.