Open AccessAn in vivo model to study the anti-malaric capacity of plant extracts
Author(s) -
Mísael Chinchílla,
Olga M. Guerrero,
Gabriela Abarca,
Mariano Barrios,
Oscar Castro
Publication year - 2015
Publication title -
revista de biología tropical
Language(s) - English
Resource type - Journals
eISSN - 2215-2075
pISSN - 0034-7744
DOI - 10.15517/rbt.v46i1.19350
Subject(s) - in vivo , parasitemia , spleen , body weight , plasmodium berghei , biology , pharmacology , traditional medicine , zoology , medicine , immunology , endocrinology , microbiology and biotechnology , malaria , plasmodium falciparum
An in vivo model to study lhe antimalarie ctfeet 01' plant extraets is described. White mi ce (25-30g body weight) are lreated subeutaneously with 0.6ml of the diluted extraet stUlling seven days before P. ber¡:heí infeetion: trealmenl eontinlles lIntil death or for 30 days. Simultaneously 0.2ml of the extraet are applied per os stming three days befare infection. In a test 01' the model, treated and non-treated animals differed in body weight, survival time, haematocrite, parnsitemia development, and spleen or liver weight of recent dcad 01' killed mice.