Open AccessExtended Hildebrand solubility approach applied to some structurally related sulfonamides in ethanol + water mixtures
Author(s) -
Daniel Ricardo Delgado,
María Ángeles Peña,
Fleming Martínez
Publication year - 2016
Publication title -
revista colombiana de química/revista colombiana de quimica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.139
H-Index - 7
eISSN - 2357-3791
pISSN - 0120-2804
DOI - 10.15446/rev.colomb.quim.v45n1.57201
Subject(s) - hildebrand solubility parameter , solubility , chemistry , sulfamerazine , thermodynamics , sulfadiazine , solvent , flory–huggins solution theory , chromatography , organic chemistry , physics , biochemistry , polymer , antibiotics
Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K. Reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations. In particular, a good predictive character of EHSA (with mean deviations lower than 3.0%) has been found by using regular polynomials in order four correlating the interaction parameter W with the Hildebrand solubility parameter of solvent mixtures without drug. However, the predictive character of EHSA was the same as that obtained by direct correlation of drug solubilities with the same descriptor of polarity of the cosolvent mixtures.