Open AccessФАРМАКО–ТОКСИКОЛОГІЧНА ОЦІНКА ПРЕПАРАТУ «ЦИФЛУР»
Author(s) -
Liudmyla Nagorna
Publication year - 2016
Publication title -
naukovij vìsnik lʹvìvsʹkogo nacìonalʹnogo unìversitetu veterinarnoï medicini ta bìotehnologìj ìmenì s.z. g̀žicʹkogo
Language(s) - English
Resource type - Journals
eISSN - 2518-1327
pISSN - 2413-5550
DOI - 10.15421/nvlvet7149
Subject(s) - palpation , active ingredient , swelling , positive control , chemistry , chromatography , medicine , pharmacology , surgery , traditional medicine , pathology
The results of pharmaco–toxicological evaluation insectoacaricid preparation «Tsiflur», in particular the study of locally irritating effect of the drug on the skin and mucous membranes of rabbits eyes. The preparation «Tsiflur» – representative of synth pyrethroids, in its composition has the active ingredient cyfluthrin, production NPF «Brovafarma». According to the manufacturer's instructions, the preparation recommended for the control of flying midges and other representatives akaroentomofauny that have veterinary importance. The tool is a clear oily solution of a yellowish color.Experimental studies were conducted on rabbits analogues in several stages. In the first phase we studied local irritant effect of the preparation in varying degrees of dilution when applied to intact skin of rabbits. The aim of the second stage of the research was to determine the local irritant effect of the d preparation on the mucous membrane of the eyes of rabbits.It has been established that the preparation «Tsiflur» in the test concentration (1: 100, 1: 200, 1: 400 concentrate solution) during the observation period did not show locally irritating effects in a single application to the intact areas of the skin of rabbits. Monitoring the bellies of the experiment showed no redness, swelling, thickening of the skin folds and the pain response to palpation place application of the preparation. Not set also signs of toxic effects of native preparation «Tsiflur», when applied under similar conditions. The reaction of the skin of animals per application experimental preparation was valued at 0 points. In the study of the preparation in a similar concentration on the possibility of providing local irritant effect on the mucous membrane of the eyes of rabbits determined that the native application of the preparation led to the emergence of a slight reddening of the eye mucosa and the appearance of watery eyes. These symptoms disappear without any intervention on the second day of the experiment. The reaction to the introduction of the preparation «Tsiflur» was estimated at 1 point, for each identified symptom.