Open AccessКІСТОЗНА ГІПЕРПЛАЗІЯ ЕНДОМЕТРІЮ ЯК ПРИЧИНА НЕПЛІДНОСТІ У САМОК СОБАК, ДІАГНОСТИКА ТА ЛІКУВАННЯ
Author(s) -
Н. Г. Давыденко
Publication year - 2016
Publication title -
naukovij vìsnik lʹvìvsʹkogo nacìonalʹnogo unìversitetu veterinarnoï medicini ta bìotehnologìj ìmenì s.z. g̀žicʹkogo
Language(s) - English
Resource type - Journals
eISSN - 2518-1327
pISSN - 2413-5550
DOI - 10.15421/nvlvet6613
Subject(s) - medicine , infertility , creatinine , hyperplasia , endocrinology , physiology , hormone , pyometra , pregnancy , biology , uterus , genetics
The article describes the pathogenesis of infertility with cystic endometrial hyperplasia, features of diagnosis and treatment. The data on changes in hormonal, morphological and biochemical blood parameters in infertile female dogs with cystic endometrial hyperplasia before and after treatment.The study involved 11 infertile females dogs with cystic endometrial hyperplasia and 5 female dogs with the normal function of the reproductive system from 2 to 6 years. Blood was collected during anoestrus and metestrus. For the treatment used broad-spectrum antibiotics, mifepristone, cloprostenol and cabergoline. Females were fertilized again after treatment to test effectiveness of the treatment. Found that sick animals have characteristic changes in morphology and biochemistry of blood. Certain amount of the female dogs have the same changes in the blood after treatment. We observed the following changes in the morphology of the blood during metestrus in the animals before treatment and a group of animals that were not pregnant after treatment and repeated mating: increase in the number of white blood cells, increasing the number of band neutrophils, the increase in the index of neutrophil shift. In the study of biochemical blood indices we have seen elevated activity of alkaline phosphatase, ALT, protein, creatinine, urea in animals that did not become pregnant after a treatment compared with the control animals group.During the study of hormone profile blood significant differences data of thyroxine in female dogs before and after treatment compared with the control group are not established. Patients in groups of animals and the animals from which failed to get offspring after treatment lowered levels of progesterone in metestrus while estradiol increased compared with the control group females. The paper adrenal experimental animals also observed changes. Thus, the function of the adrenal glands increases significantly during metestrus, as the level of DHEA-S and cortisol increased. However, cortisol and DHEA-S was lowest in sick animals for treatment and a group of animals that fail to conceive after treatment. It gives grounds to assume that adrenal’s hormones take part in the pathogenesis of female infertility dogs with cystic endometrial hyperplasia.