Open AccessInfluence of potential nanopollutant fullerene C60 on physiological and biochemical responses in mammals
Author(s) -
V. S. Nedzvetsky,
V. Y. Gasso,
S. V. Yermolenko,
I. A. Hasso
Publication year - 2021
Publication title -
pitannâ stepovogo lìsoznavstva ta lìsovoï rekulʹtivacìï zemelʹ
Language(s) - English
Resource type - Journals
ISSN - 2073-8331
DOI - 10.15421/442106
Subject(s) - fullerene , cytotoxicity , oxidative stress , chemistry , lipid peroxidation , insulin resistance , nanotoxicology , insulin , pharmacology , biophysics , biochemistry , microbiology and biotechnology , biology , toxicity , endocrinology , in vitro , organic chemistry
The progressive development of technologies in the manufacture and application of nanomaterials in almost all spheres of human life causes penetration in an organism and accumulation of nanoparticles in its cells. Determinations of the risk of using nanomaterials and mechanisms of their cytotoxicity are extremely relevant current problems that should be studied. Fullerene C60 is the most widespread nanomaterial proposed to use inhibition of tumour growth, microbial infections, and purposeful drug delivery. However, there are contradictory data on cytotoxic and/or cytoprotective effects of this fullerene. In the present paper, the action of fullerene C60 on glucose metabolism, the composition of the intestinal microbiota, and an acid-reducing balance were studied in rats. It is shown that fullerene C60 dissolved in olive oil (2 mg/kg/day) induces insulin resistance, activates the peroxidation of lipids in the brain of animals, but not in the liver, under conditions of chronic influence. In addition, fullerene C60 induced changes in the composition of the intestinal microbiota in rats. Determined disorders may be a cause of insulin production, as an adaptive response to the needs of metabolic energy under local oxidative stress in the nerve tissue. At the same time, the growth of insulin resistance can be induced by nonspecific molecular damage in biomembranes and macromolecules, including insulin receptors. In this regard, the explanation of the molecular mechanisms of insulin resistance induced by fullerene C60 together with the effect of fullerene dose will be of particular interest in further studies.