Open AccessDynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty
Author(s) -
B. V. Gutyj,
K. Y. Leskiv,
A. R. Shcherbatyy,
В. В. Прицак,
V. V. Fedorovych,
O. V. Fedorovych,
V. Rusyn,
І. А. Kolomiiets
Publication year - 2017
Publication title -
regulatory mechanisms in biosystems
Language(s) - English
Resource type - Journals
eISSN - 2520-2588
pISSN - 2519-8521
DOI - 10.15421/021766
Subject(s) - haptoglobin , alkaline phosphatase , medicine , albumin , blood proteins , endocrinology , sialic acid , femoral neck , surgery , gastroenterology , biochemistry , chemistry , osteoporosis , enzyme
The importance of biomarkers to predict recovery following total hip arthroplasty (THA) is still unclear to clinicians. To assess the preoperative biomarkers of patients with pseudoarthrosis of the femoral neck and their dynamics in the early postoperative period after THA, 50 patients aged 33 to 82 years old, 18 males and 32 females diagnosed with pseudoarthrosis of the femoral neck after failed internal fixation and failed conservative management were studied. The control group consisted of 30 healthy people aged 27 to 50 years, 13 males, 17 females. Patients’ blood was examined for biochemical markers upon admission, and then on the 7th and 14th days after surgery. Their blood serum content of total protein, albumin, glycoproteins, sialic acids, chondroitin sulfates, haptoglobin, glucose, cholesterol, triglycerides, ALT, AST, alkaline phosphatase, GGT, acid phosphatase, thymol index; interleukins (IL-1, IL-4 and IL-6.) and C-reactive protein was measured. The content of glycoproteins in the blood exceeded normal by 2.3 times, chondroitin sulfate by 4.7 times, sialic acids by 1.5 times, haptoglobin by 55.8%, fibrinogen by 19.1%, globulin by 19,6%, alkaline phosphatase activity by 72.3%, IL-1 by 94.7 and IL-6 by 3 times, C-reactive protein by 2.6 times. After THA there was a gradual decrease in blood biochemical and immunological markers. The most informative laboratory markers were glycoproteins, chondroitin sulfates, sialic acids, haptoglobin, activity of alkaline phosphatase, IL-1, IL-6 and IL-4, and C-reactive protein. Subsequent research is required to validate these dynamics.