Open AccessAtrial Fibrillation, Cognitive Decline and Dementia
Author(s) -
Álvaro Alonso,
Antonio P. Arenas-de Larriva
Publication year - 2016
Publication title -
european cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 12
eISSN - 1758-3764
pISSN - 1758-3756
DOI - 10.15420/ecr.2016:13:2
Subject(s) - dementia , atrial fibrillation , cognitive decline , medicine , cognition , stroke (engine) , cardiology , risk factor , observational study , epidemiology , incidence (geometry) , psychiatry , disease , mechanical engineering , physics , optics , engineering
Atrial fibrillation (AF) is a common cardiac arrhythmia. Growing evidence supports a role for AF as a risk factor for cognitive decline and dementia. In this review, we summarize epidemiologic observations linking AF with cognitive outcomes, describe potential mechanisms, and explore the impact of AF treatments on cognitive decline and dementia. Community-based, observational studies show a consistent higher rate of cognitive decline and risk of dementia in persons with AF. These associations are partly due to the increased risk of clinical stroke in AF, but other mechanisms, including incidence of silent cerebral infarcts, microbleeds, and cerebral hypoperfusion, are likely additional contributors. Adequate oral anticoagulation and improved management of the overall cardiovascular risk profile in persons with AF offer the promise of reducing the impact of AF on cognitive decline and dementia.