Open AccessTherapeutic potential of curcumin against lead-induced toxicity: A review
Author(s) -
Kabeer Abubakar,
Maryam Muhammad Mailafiya,
Abubakar Danmaigoro,
Ezamin Abdul Rahim,
Zuki Abu Bakar
Publication year - 2019
Publication title -
biomedical research and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 1
ISSN - 2198-4093
DOI - 10.15419/bmrat.v6i3.528
Subject(s) - curcumin , curcuma , toxicity , pharmacology , oxidative stress , reactive oxygen species , antioxidant , curcuminoid , medicine , chemistry , traditional medicine , biochemistry
Lead poisoning causes numerous clinical implications in almost all organs, with the brain, liver, and kidneys serving as the primary targets due to the abundant presence of mitochondria. Curcumin is one of the most potent constituents of Curcuma longa, which is lipophilic, phenolic and water insoluble. Curcumin is a strong antioxidant and anti-inflammatory agent in the treatments of neurodegenerative disease, cardiovascular, renal, and liver diseases, with a potential anticancer mechanism in a few clinical and experimental trials. This review will focus on the health impact of lead-induced toxicity in different organ-systems, which occurs as result of increased oxidative stress through the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and will discuss the therapeutic potential of curcumin against lead-induced toxicity in both human and animals.