Open AccessID: 1028 Comparison of HER2 status in gastric adenocarcinoma patients between gastrectomy specimens and matched endoscopic specimens
Author(s) -
Cuong Pham Hung,
Hoang Yen Tran Nu
Publication year - 2017
Publication title -
biomedical research and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 1
ISSN - 2198-4093
DOI - 10.15419/bmrat.v4is.304
Subject(s) - concordance , medicine , gastrectomy , adenocarcinoma , gastroenterology , biopsy , cancer , immunohistochemistry , endoscopy , pathology
Background: To evaluate the concordance between HER2 status in both surgical specimens and matched endoscopic specimens of gastric adenocarcinoma patients.
Methods: Records of 52 patients with gastric adenocarcinoma diagnosed by upper GI endoscopy, treated by gastrectomy and Her2 status assessed (by immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH)) from June 2014 through July 2016 in HCMC Oncology Hospital were studied and presented in case series. Her2-positive status was defined by a score 3+ in IHC, or 2+ with a positive FISH test.
Results: + Her2-positive status was identified in 9.6%.
+ The concordance of Her2 status between endoscopic biopsy and surgical specimens was 98% (Kappa=0.879).
Conclusion: + There was a very high concordance between the Her2 status results performed on surgical specimens and matched endoscopic specimens.
+ Her2 status assessed on endoscopic biopsy specimens could be reliable for treatment decisions using anti-Her2 agents in patients with advanced gastric carcinoma