Open AccessID2010 Cytotoxicity of aqueous and ethanolic bark extracts of Pithecellobium dulce against human carcinoma cells
Author(s) -
Shella Mae Jalique
Publication year - 2017
Publication title -
biomedical research and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 1
ISSN - 2198-4093
DOI - 10.15419/bmrat.v4is.253
Subject(s) - traditional medicine , cytotoxicity , bark (sound) , hepatic carcinoma , toxicity , hepatocellular carcinoma , viability assay , mtt assay , aqueous extract , colorectal cancer , pharmacology , chemistry , medicine , cancer , biology , cell , in vitro , biochemistry , cancer research , ecology
Cancer cases continue to increase and kill humans. In this paper, we report a study based on anticancer properties of the aqueous and ethanolic bark extracts of Pithecellobium dulce. Anticancer activities were assayed with standard MTT colorimetric procedure against three human cancer cell lines namely breast (MCF-7), colon (HCT-116), and hepatocellular (HepG2) in different concentrations. The aqueous extract of the plant revealed the highest toxicity on hepatocellular carcinoma (HepG2) cancer cell line with cell viability of 1.71 percent. On the other hand, its ethanol extracts has the highest toxicity on colon carcinoma (HCT-116) with a percent viability of 6.05 percent. Based on the results, the bark of the plant can be used to prepare anticancer drug with proper standardization methods