Open AccessID3009 Gelatin-Poly (Ethylene Glycol) Methyl Ether-Functionalized Porous Nanosilica for Controlled Doxorubicin Delivery
Author(s) -
Hai Dai Nguyen
Publication year - 2017
Publication title -
biomedical research and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 1
ISSN - 2198-4093
DOI - 10.15419/bmrat.v4is.229
Subject(s) - nanocarriers , ethylene glycol , gelatin , materials science , drug delivery , peg ratio , doxorubicin , nanoparticle , conjugated system , chemical engineering , chemistry , nanotechnology , organic chemistry , polymer , composite material , surgery , medicine , finance , chemotherapy , engineering , economics
Porous nanosilica (PNS) has been attracting a growing attention in fabrication of carriers for drug delivery system (DDS). However, unmodified PNS-based nanocarriers exhibit the initial burst release of encapsulated bioactive molecules, which may limit their potential clinical applications. In this report, the surface of PNS was conjugated with gelatin-poly (ethylene glycol) methyl ether (GEL-mPEG) to form a core-shell structure PNS-GEL-mPEG for doxorubicin (DOX) delivery. The conjugated PNS carriers were found to be spherical in shape with diameter range of approximately 55-85 nm as compared with their parentally PNS (55-67 nm). The PNS-GEL-mPEG nanoparticles showed their ability to effectively encapsulate DOX for controlled release. In detail, DOX was efficiently loaded into the PNS-GEL-mPEG to form DOX-loaded nanocarriers (DOX@PNS-GEL-mPEG) with high loading efficiency (79.7%). The release of DOX from DOX@PNS-GEL-mPEG was prolonged and controlled up to 96 h in phosphate buffered saline (PBS, pH 7.4, 37 oC) without any initial burst release. These results demonstrated that this PNS-GEL-mPEG can be a potential candidate for controlled DDS with high loading capacity in cancer therapy