Open AccessImproving stem cell engraftment to enhance functional efficacy in cardiovascular disease: where are we now?
Author(s) -
Anh Thi-Van Bui,
Truc Le-Buu Pham,
Jitka A. I. Virag
Publication year - 2017
Publication title -
biomedical research and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 1
ISSN - 2198-4093
DOI - 10.15419/bmrat.v4i1.146
Subject(s) - stem cell , medicine , transplantation , disease , genetic enhancement , immunology , cell therapy , stem cell therapy , cancer research , bioinformatics , biology , microbiology and biotechnology , gene , biochemistry
Stem cell therapy is a promising therapy for repairing damaged tissue. A growing body of research shows that stem cells work effectively in several diseases such as cardiovascular disease, hepatic disease, and diabetes. It has been shown that stem cells not only differentiate into functional cells and replace dead cells, but also release growth factors and cytokines which can recruit autologous cells. The most significant barrier to achieve clinical relevance of this treatment mode is the poor survival rate of injected cells. To improve transplantation and enhance functional outcome, investigations of gene transfection (overexpression of anti-apoptotic and antioxidant proteins), growth factor supplementation, and scaffolding matrices are being conducted. In this review, we will focus on methods to increase cell survival in stem cell transplantation as a novel treatment for cardiovascular disease.