Open AccessEffect of IgG from multiple sclerosis patients on amidolytic activity of coagulation and anticoagulation factors of hemostasis
Author(s) -
T. Katrii,
Shandyuk V.Yu.,
Tetiana Vovk,
Tetiana Halenova,
Nataliia Raksha,
O V Shershnov,
Volodymyr Melnyk,
О. Savchuk,
Л. И. Остапченко
Publication year - 2017
Publication title -
biomedical research and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 1
ISSN - 2198-4093
DOI - 10.15419/bmrat.v4i08.205
Subject(s) - coagulation , immunoglobulin g , multiple sclerosis , hemostasis , immunology , antibody , medicine , thrombin , immunoglobulin a , platelet
Background: Immunoglobulin G (IgG) is a major immunoglobulin (Ig) in blood that accumulates to a greater extent in the bloodstream of patients impacted by neuroimmunological disorders such as multiple sclerosis (MS). The aim of this study was to determine the effect of IgG obtained from MS patients on the amidolytic activity of coagulation and on anticoagulation factors, and to compare those effects to the effects of IgG from healthy donors.
Methods: Spectrophotometric hydrolysis of specific chromogenic substrate by key haemostasis factors was examined.
Results: Our study shows that unlike healthy individuals, patients suffering from MS express IgG which enhances the amidolytic activity of thrombin and protein C, but inhibits the activity of factor Xa.
Conclusion: Our study shows that IgG and coagulation factors, indeed, interact with each other. IgG may be key mediators of neuroinflammation and, therefore, may serve as a potential target for therapeutic strategies for MS and other neuroimmunological diseases.