Open AccessRole of Protein Kinase C in Diabetic Complications
Author(s) -
. Simran,
Amarjot Kaur Grewal,
Sandeep Arora,
Thakur Gurjeet Singh
Publication year - 2019
Publication title -
journal of pharmaceutical technology research and management
Language(s) - English
Resource type - Journals
eISSN - 2321-2225
pISSN - 2321-2217
DOI - 10.15415/jptrm.2019.72011
Subject(s) - polyol pathway , protein kinase c , medicine , diabetes mellitus , glycation , nephropathy , signal transduction , diabetic neuropathy , endocrinology , bioinformatics , chemistry , biology , biochemistry , aldose reductase
Diabetes is the most common and systemic disorder associated with hyperglycemia which is the significant factor in the development of micro- and macrovascular changes. Many mechanistic approaches i.e. activation of Protein kinase C, glycation end products production, hexosamine pathway and polyol pathway induce cellular damage and lead to the development of diabetic complications like nephropathy, neuropathy, retinopathy, and myopathy. One of the adverse effects of long-lasting hyperglycemia is activation of PKC (intracellular signaling enzyme) and has become a field of great research interest. Hence, in this review special emphasis is placed on microvascular complications which are due to activation of PKC. Clinical trials have also been conducted using selective PKC inhibitors and have shown positive results against hyperglycemia.