Open AccessCharacteristic Changes in the Density and Shear Viscosity of Human Blood Plasma with Varying Protein Concentration
Author(s) -
N. P. Malomuzh,
Л. А. Булавин,
V. Ya. Gotsulskyi,
A. A. Guslisty
Publication year - 2020
Publication title -
ukrainian journal of physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.213
H-Index - 17
eISSN - 2071-0194
pISSN - 2071-0186
DOI - 10.15407/ujpe65.2.151
Subject(s) - biomaterial , albumin , blood proteins , shear (geology) , viscosity , chemistry , blood plasma , fibrinogen , materials science , shear modulus , plasma , blood viscosity , human blood , biophysics , thermodynamics , biochemistry , composite material , nanotechnology , biology , medicine , physics , quantum mechanics , physiology
The density and shear viscosity of human blood plasma and their dependence on the concentration of proteins (albumin, y-globulin, fibrinogen, etc.) entering the natural blood composition have been studied. The biomaterial concentration is varied by diluting the blood plasma with the isotonic aqueous solution. It is shown that a decrease in the biomaterial concentration down to 0.91 of its initial value leads to a drastic change in the plasma density and to a change in the character of the concentration dependence of the shear viscosity of blood plasma. A hypothesis is put forward that the observed changes in the density and shear viscosity result from the structural transformations induced by oligomerization processes; first of all, by the albumin dimerization. A conclusion is drawn that the introduced blood substitutes should not exceed 10% of the blood mass; otherwise, structural transformations of a biomaterial in blood plasma can be provoked.