Open AccessFluorecently Labeled Bionanotransporters of Nucleic Acid Based on Carbon Nanotubes
Author(s) -
Д. С. Новопашина,
Evgeny Apartsin,
A. G. Ven’yaminova
Publication year - 2012
Publication title -
ukrainian journal of physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.213
H-Index - 17
eISSN - 2071-0194
pISSN - 2071-0186
DOI - 10.15407/ujpe57.7.718
Subject(s) - carbon nanotube , oligonucleotide , pyrene , nucleic acid , fluorescein , covalent bond , surface modification , carbon fibers , materials science , stacking , fluorescence , chemistry , organic chemistry , nanotechnology , dna , biochemistry , physics , quantum mechanics , composite number , composite material
We propose an approach to the design of a new type of hybrids of oligonucleotides with fluorescein-functionalized single-walled carbon nanotubes. The approach is based on stacking interactions of functionalized nanotubes with pyrene residues in conjugates of oligonucleotides. The amino- and fluorescein-modified single-walled carbon nanotubes are obtained, and their physico-chemical properties are investigated. The effect of the functionalization type of carbon nanotubes on the efficacy of the sorption of pyrene conjugates of oligonucleotides was examined. The proposed non-covalent hybrids of fluorescein-labeled carbon nanotubes with oligonucleotides may be used for the intracellular transport of functional nucleic acids.