Open AccessCirrhosis risk score of the donor organ predicts early fibrosis progression after liver transplantation
Author(s) -
Anca Zimmermann,
Felix Darstein,
Maria HoppeLotichius,
Gerrit Toenges,
Anja Lautem,
Frédéric Abel,
Arno Schad,
Jens Mittler,
Johanna Vollmar,
Dorothee Grimm,
Hauke Lang,
Peter R. Galle,
Tim Zimmermann,
Detlef Schuppan
Publication year - 2019
Publication title -
journal of gastrointestinal and liver diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 48
eISSN - 1842-1121
pISSN - 1841-8724
DOI - 10.15403/jgld.2014.1121.281.crr
Subject(s) - medicine , cirrhosis , gastroenterology , liver transplantation , hazard ratio , fibrosis , cohort , cumulative incidence , genotype , incidence (geometry) , transplantation , hepatitis c , confidence interval , gene , biochemistry , chemistry , physics , optics
Fibrosis progression (FP) after liver transplantation (LT) increases morbidity and mortality. Biomarkers are needed for early prediction of FP. A recipient's seven-gene cirrhosis risk score (CRS) has been associated with FP, especially in non-transplant cohorts. A broader validation of CRS, including the genotype of the donor-organ and HCV-negative patients is lacking. We therefore analyzed the impact of donor- and recipient-specific genotypes on FP after LT in a large cohort of HCV-positive and -negative patients.