Open AccessLiver Adverse Outcome Pathways: What’s in for the Hepatologist?
Author(s) -
Mathieu Vinken
Publication year - 2020
Publication title -
journal of gastrointestinal and liver diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 48
eISSN - 1842-1121
pISSN - 1841-8724
DOI - 10.15403/jgld-2809
Subject(s) - adverse outcome pathway , medicine , adverse effect , intensive care medicine , outcome (game theory) , liver disease , hepatology , medline , bioinformatics , computational biology , mathematics , mathematical economics , political science , law , biology
Adverse outcome pathways are tools to capture and visualize mechanisms underlying adverse effects, and are currently emerging in the areas of toxicology and chemical risk assessment. Less attention has yet been paid to potential clinical applications of adverse outcome pathways, including in the hepatology field. Liver adverse outcome pathways can serve the development and optimization of the clinically relevant animal models of liver diseases for fundamental and translational research as well as for testing new liver therapeutics. They also can aid the characterization of novel and more specific diagnostic and prognostic biomarkers of liver disease. Full clinical exploitation in these directions requires further technical optimization of adverse outcome pathways as well as intensive interdisciplinary and intersectoral collaboration.