Open AccessParaoxonase 1 Correlates with Butyrylcholinesterase and Gamma Glutamyl Transferase in Workers Chronically Exposed to Pesticides
Author(s) -
Araoud Manel,
Neffeti Fadoua,
Douki Wahiba,
Najjar Mohamed Fadhel,
Kenani Abderraouf
Publication year - 2010
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.o10017
Subject(s) - butyrylcholinesterase , paraoxonase , pon1 , pesticide , aryldialkylphosphatase , creatine kinase , lactate dehydrogenase , alkaline phosphatase , cholinesterase , organophosphate , chemistry , oxon , toxicity , medicine , enzyme , toxicology , pharmacology , biochemistry , acetylcholinesterase , biology , aché , psychiatry , genotype , agronomy , gene
Paraoxonase 1 Correlates with Butyrylcholinesterase and Gamma Glutamyl Transferase in Workers Chronically Exposed to Pesticides: Manel A raoud , et al . Laboratory of Biochemistry 05/UR/09‐09, Faculty of Medicine of Monastir, TunisiaObjectives Agricultural workers chronically exposed to complex mixtures of pesticides are at increased risk of acute and chronic toxicity of these compounds. Enzyme activities are among the biomarkers that may be used to detect the effects of pesticides before adverse clinical health effects occur. The aims of this study were to ascertain the relationships between paraoxonase 1 (PON1) and other serum enzymes and to investigate whether long‐term exposure to pesticides affects these relationships in Tunisian agricultural workers. Methods The activities of butyrylcholinesterase (BChE), aminotransferases, gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) were measured in plasma from workers chronically exposed to pesticides using an Integra 400 plus™ system. PON1 activity was measured using konelab 30™ system. Results Significant increases in aminotransferases, CK, LDH and ALP activities were found in workers exposed to pesticides. However, BChE and PON1 activities were decreased significantly in these subjects. In addition, PON1 activity was positively correlated with both BChE and GGT activities in these workers. Conclusion This study suggests that pesticides lead to alteration of serum enzymes and that chronic exposure to pesticides might contribute to explain the positive correlation between PON1 and GGT, perhaps in order to protect BChE and simultaneously induce detoxification of pesticides.