Open AccessMatrix Metalloproteinase‐3 and Vitamin D Receptor Genetic Polymorphisms, and Their Interactions with Occupational Exposure in Lumbar Disc Degeneration
Author(s) -
Yuan HanYan,
Tang Ying,
Liang YouXin,
Lei Ling,
Xiao GuoBing,
Wang Sheng,
Xia ZhaoLin
Publication year - 2010
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.l8149
Subject(s) - calcitriol receptor , allele , medicine , lumbar , genetics , vitamin d and neurology , endocrinology , pathology , biology , gene , anatomy
Matrix Metalloproteinase‐3 and Vitamin D Receptor Genetic Polymorphisms, and Their Interactions with Occupational Exposure in Lumbar Disc Degeneration: Han‐Yan Y uan , et al . Department of Occupational Health, School of Public Health, Fudan University, ChinaObjectives To investigate the occupational and genetic risk factors inducing lumbar disc degeneration in a Chinese population, and to explore their synergistic interactions. Methods A case‐control study involving 178 low back pain patients with lumbar disc degeneration and 284 controls was carried out. Five types of work‐related factors were investigated using questionnaires. Polymerase chain reaction and restriction fragments length polymorphism was used to detect the polymorphisms of MMP‐3 (matrix metalloproteinase‐3)(rs731236), VDR‐Taq (vitamin D receptor‐Taq) and VDR‐Apa (vitamin D receptor‐Apa)(rs35068180). Rothman's synergy index was used to measure the synergistic interactions between gene polymorphisms and occupational risk factors. Results Family history of lumbar disc diseases, back injury history, whole‐body vibration, bending/twisting, heavy physical workload, age, mutation alleles 5A of MMP‐3 and A of VDR‐Apa were significantly associated with lumbar disc degeneration (OR=12.70, 11.79, 8.96, 5.46, 1.05, 1.96 and 1.70, respectively, p <0.05). Synergistic interactions existed between the mutation allele 5A of MMP‐3 and whole‐body vibration exposure, the mutation allele 5A of MMP‐3 and bending/twisting, and the mutation allele A of VDR‐Apa and bending/twisting (SI=13.27, 2.91, 2.35, respectively, p <0.05). Conclusions The results of this study suggest that gene‐occupation interaction might play a certain role in exaggerating lumbar disc degeneration. There is a possibility that subjects who carry mutation alleles 5A of MMP‐3 and/or A of VDR‐Apa are more vulnerable to lumbar disc degeneration when they are exposed to whole‐body vibration and/or bending/twisting under ergonomic loads.