Open AccessEffects of Lifestyle on Urinary 1‐hydroxypyrene Concentration
Author(s) -
Kawamoto Toshihiro,
Yang Mihi,
Kim YongDae,
Kim Heon,
Oyama Tsunehiro,
Isse Toyohi,
Matsuno Koji,
Katoh Takahiko,
Uchiyama Iwao
Publication year - 2007
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.49.183
Subject(s) - urine , environmental health , medicine , urinary system , cigarette smoking , metabolite , toxicology , black tea , physiology , food science , chemistry , biology
Effects of Lifestyle on Urinary 1‐hydroxypyrene Concentration: Toshihiro K awamoto , et al . Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Japan —This study aimed to clarify the variation of urinary excretion of 1hydroxypyrene, which is a major metabolite of pyrene, in relation to lifestyle, including factors such as diet and smoking. The study subjects were 251 workers (male: 196, female: 55, mean age: 44.3) who were not occupationally exposed to PAHs. Urine specimens were collected from 8:00 a.m. to 11:00 a.m. and their 1‐hydroxypyrene concentrations were determined by HPLC. A questionnaire was distributed in order to learn gross aspects of the subjects' lifestyles, i.e., smoking, alcohol consumption, coffee/black tea intake, and dietary habits. Multiple linear regression analysis revealed that cigarette consumption most strongly affected the 1‐hydroxypyrene level in urine, followed by dietary balance. The urinary 1‐hydroxypyrene concentrations of smokers were about 2 times higher than those of non‐smokers. Subjects who ate more meat and/or fish excreted 1.5‐2 times more 1hydroxypyrene in urine than those who ate more vegetables.