Open AccessWhole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1‐Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics
Author(s) -
Choi Younghee,
Park Ji Kang,
Park Neung Hwa,
Shin Jung Woo,
Yoo CheolIn,
Lee Choong Ryeol,
Lee Hun,
Kim Hyo Kyung,
Kim SungRyul,
Jung Taehum,
Park Jungsun,
Yoon Chung Sik,
Kim Yangho
Publication year - 2005
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.47.68
Subject(s) - cirrhosis , magnetic resonance imaging , red blood cell , nuclear magnetic resonance , chemistry , liver transplantation , manganese , nuclear medicine , medicine , pathology , transplantation , radiology , physics , organic chemistry
Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1‐Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics: Younghee Choi, et al. Department of Occupational and Environmental Medicine, Ulsan University Hospital, South Korea —We examined whole blood (MnB), red blood cell (MnRBC), plasma (MnP) and urinary Mn (MnU) concentrations in 22 liver cirrhotics and 10 healthy controls to evaluate Mn concentration in which a fraction of biological samples best reflects pallidal signal intensities (pallidal index; PI) on T1‐weighted magnetic resonance images (MRI) in liver cirrhotics. Increased signal intensity in the globus pallidus was observed in 18 (81.8%) of the 22 patients with liver cirrhosis. In a transplanted patient, increased pallidal signals also resolved as his liver function tests normalized after liver transplantation. There were significant correlations between MnB/MnRBC and PI (ρ=0.529, ρ=0.573, respectively) in liver cirrhotics, although no significant correlation was observed between MnP/MnU and PI. According to a multiple linear regression, MnB and MnRBC reflected the signal intensities of T1‐weighted MRI better than MnP or MnU.