Open AccessEffects of Prednisolone and Complex of Vitamin B 1 , B 2 , B 6 and B 12 on Organophosphorus Compound‐Induced Delayed Neurotoxicity
Author(s) -
Piao Fengyuan,
Ma Ning,
Yamamoto Hidetaka,
Yamauchi Toru,
Yokoyama Kazuhito
Publication year - 2004
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.46.359
Subject(s) - prednisolone , ataxia , group b , medicine , vitamin , endocrinology , group a , chemistry , psychiatry
Effects of Complex of Prednisolone and Vitamin B 1 , B 2 , B 6 and B 12 on Organophosphorus Compound‐Induced Delayed Neurotoxicity: Fengyuan Piao, et al. Department of Public Health, School of Medicine, Mie University —Protective effects of prednisolone as a synthetic adrenal cortical hormone and complex of vitamin B 1 , B 2 , B 6 and B 12 on organophosphorus compound‐induced delayed neurotoxicity (OPIDN) caused by leptophos and tri‐ocresyl phosphate (TOCP) as organophosphates (OPs) were examined. Nine groups of hens (six for each) were used. Eight groups received intravenous injection of 30 mg/kg of leptophos or 40 mg/kg of TOCP (four groups in each). Among them, three groups which received leptophos were given (p.o.) predonisolone (2 mg/body), vitamin B complex (25 mg/body) or both 3 h after OPs injection and then every day for 15 d (one group for each); the same treatment was performed on three groups which received TOCP. The remaining one group served as controls. It was observed that delayed neuropathy induced by OPs could not be resisted completely by the treatment with prednisolone or vitamin B complex, but clinical signs of OPIDN and pathological changes in hens that received these two protective agents after OPs were less severe than those in hens that received only OPs. Of these groups, the improvement in clinical signs was best shown in hens that received the both two protective agents. In addition, improvement in clinical signs among the hens that did not deteriorate to paralysis was observed. In particular, those which developed mild ataxia recovered well. It is indicated that combining administration of prednisolone and vitamin B complex early before clinical signs are manifest is effective in alleviating neuropathy. It is also suggested that recovery or good prognosis will be expected, as long as progression of the clinical signs is prevented before paralysis develops in delayed neuropathy.