Open AccessPulmonary Squamous Cyst Induced by Exposure to Indium Arsenide in Hamsters
Author(s) -
Tanaka Akiyo,
Hirata Miyuki,
Omura Minoru
Publication year - 2003
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.45.405
Subject(s) - medical school , hygiene , medicine , citation , library science , medical education , family medicine , computer science , pathology
Indium arsenide (InAs) belongs to the group of semiconductor materials comprising III-V compounds . With the increasing industrial use of InAs, the question as to whether or not occupational exposure to this material is a potential health hazard has been attracting attention. To date, there is no information regarding adverse health effects on workers arising from their exposure to InAs particles. In our previous study, we confirmed the development of proteinosis-like lesions or localized hyperplastic lesions in the lungs of hamsters which had been induced by exposure to InAs particles. In particular, alveolar or bronchiolar cell hyperplasia with squamous cell metaplasia, squamous cell hyperplasia or squamous cell metaplasia with keratinization were observed when 7.7 mg/kg of InAs was instilled intratracheally, twice a week for a total of 14 times. Accordingly, a further study was undertaken with only half the dose (4 mg/kg). As a result, neoplastic change was never evident. We therefore considered that it was necessary to use a dose in excess of 4 mg/kg of InAs per instillation in order to give rise to a neoplastic response. The aim of the present study was to confirm whether the localized hyperplastic lesions induced by the overloaded condition of InAs particles actually represented a neoplastic response, or not. In this study, 8 mg/kg of InAs was instilled and double the number of hamsters (n=16), compared with that (n=8) in the previous study, received the particles.