Open AccessSingle Exposure to Gasoline or Ether Reduces Cytochrome P‐450 Activities without Affecting UDP‐Glucuronosyltransferase Activity in Rat Liver
Author(s) -
Ida Seiko,
Yokota Masayuki,
Yoshioka Hiroshi,
Takiguchi Yoshiharu
Publication year - 2000
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.42.84
Subject(s) - clinical pharmacology , medicine , pharmacology
Unleaded gasoline and ether (diethyl ether) are widely handled at self-service gas stations and laboratories. Some investigators have reported on the effects of gasoline and ether on the drug-metabolizing enzyme system: unleaded gasoline vapor induces cytochrome P450(CYP)2B in the mouse liver; xylene, one of the components of gasoline, also induces CYP1A2 and UDPglucuronosyltransferase (UGT) in the rat liver; immediately after ether inhalation, CYP2E1 is activated in the rat liver while some other CYP activities are reduced by ether. In the present study we examined the acute effects of large quantities of gasoline (a mixture) and ether (a pure substance) on the activities of CYP and UGT in rat liver microsomes.