Open AccessAcute and Repeated Inhalation Toxicity of 1‐Bromopropane in SD Rats
Author(s) -
Kim HyeonYeong,
Chung YongHyun,
Jeong JaeHwang,
Lee YongMuk,
Sur GilSoo,
Kang JongKoo
Publication year - 1999
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.41.121
Subject(s) - inhalation , medicine , toxicity , inhalation exposure , confidence interval , body weight , acute toxicity , hematology , physiology , anesthesia
Acute and Repeated Inhalation Toxicity of 1‐Bromopropane in SD Rats: Hyeon‐Yeong K im et al . Industrial Chemicals Research Center, Industrial Health Research Institute, Korea —The acute and repeated inhalation toxicity of 1‐bromopropane (1‐BP) in SD rats were investigated. LC 50 for four‐hour exposure was 14,374 ppm (95% confidence limit: 13,624‐15,596 ppm). It was revealed to be irritating to the eyes with lacrimation in all four‐hour exposure rats. No other abnormal clinical signs and gross findings related to the 1‐BP exposure were observed. An experiment on repeated exposure to 0, 50, 300, and 1,800 ppm for six hrs/day, five days/week, for eight weeks was conducted. A decrease in body weights and increase in relative liver weight in both male and female rats were observed in the 1,800 ppm exposure group (p<0.001 vs. control group). No other significant changes in feed consumption, urinanalysis, hematology and serum biochemistry were observed. Histopathological examinations did not reveal any 1‐BP‐related changes.