Open AccessThe Effects of Allyl Chloride on Ca 2+ , Ca 2+ ‐Free CaM, cAMP and Ca 2+ /CaM‐PK II Activity in Nerve Cells
Author(s) -
Xie Keqin,
Gao Shujun,
Zhang Lei,
Zhang Min,
Sun Keren
Publication year - 1998
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.40.50
Subject(s) - intracellular , chemistry , chloride , allyl chloride , nuclear chemistry , biophysics , neurotoxicity , calcium , biochemistry , toxicity , biology , catalysis , organic chemistry
The Effects of Allyl Chloride on Ca 2+ , Ca z+ ‐Free CaM, cAMP and Ca 24 /CaM‐PK II Activity in Nerve Cells: Keqin X ie , et at. Institute of Toxicology, Shandong Medical University —Nerve cells in a culture from chicken embryo brain were used to study the allyl chloride‐induced effects on the contents of intracellular Ca 2+ , Ca 2+ ‐free CaM, cAMP and the activity of Ca 2+ /CaM‐PK II. The results showed that with the increase in the concentration of allyl chloride there was a significant increase in the content of Ca 2+ and cAMP, and the activity of Ca 2 ~/CaM‐PK II in the cells (P<0.01), but a marked decrease in Ca 2 + ‐free CaM (P< 0.01). The results suggest that the neurotoxicity of allyl chloride might be related to the increase in intracellular Ca 2+ and the activation of CaM and Ca 2+ /CaM‐PK II, eventually leading to the accumulation of degenerative MT in the nerve axon.