Open AccessPulmonary Toxicity in Mice by 2‐ and 13‐week Inhalation Exposures to Indium‐tin Oxide and Indium Oxide Aerosols
Author(s) -
Nagano Kasuke,
Nishizawa Tomoshi,
Eitaki Yoko,
Ohnishi Makoto,
Noguchi Tadashi,
Arito Heihachiro,
Fukushima Shoji
Publication year - 2011
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.10-0053-br
Subject(s) - inhalation , pulmonary toxicity , pulmonary alveolar proteinosis , lung , toxicity , pathology , medicine , hyperplasia , indium tin oxide , indium , spleen , inhalation exposure , chemistry , anesthesia , organic chemistry , layer (electronics)
Pulmonary Toxicity in Mice by 2‐ and 13week Inhalation Exposures to Indium‐tin Oxide and Indium Oxide Aerosols: Kasuke Nagano, et al., Japan Bioassay Research Center, Japan Industrial Safety and Health Association—Objectives Inhalation toxicities of indium‐tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. Methods B6C3F 1 mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m 3 or 13 wk at 0, 0.1or 1 mg/m 3 . Results ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal‐associated lymphoid tissue. Alveolar proteinosis, iniltrations of alveolar macrophages and inlammatory cells and increased lung weight were induced by 2‐ and 13‐week exposures to ITO and IO, while alveolar epithelial hyperplasia occurred only in the 2‐week exposures. Thickened pleural wall, hyperplastic MLN, extra medullary hematopoiesis in the spleen and increased levels of erythrocyte parameters were induced by 13‐week exposure to ITO. The ITO‐ and IO‐induced pulmonary lesions were milder in mice than those previously reported in rats, and the ibrotic lesions were different between these two species. Indium levels in the lung and pooled blood were analyzed in the mice exposed to ITO and IO for 13 wk. In the 13‐week inhalation exposure of mice to ITO, alveolar proteinosis and significantly increased lung weight were induced at the same exposure concentration as the current threshold limit value for indium and its compounds.