Open AccessDetermination Method for Xylidines in Workplace Air
Author(s) -
Takeuchi Akito,
Yamamoto Shinobu,
Hendricks Warren,
Nishimura Yasuki,
Imanaka Tsutoshi,
Kaifuku Yuichiro,
Sakui Norihiro,
Natsumeda Shuichiro,
Ota Hirokazu,
Yamada Shu,
Kurotani Ichiro,
Sumino Kimiaki,
Kanno Seiichiro
Publication year - 2011
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1539/joh.10-0003-br
Subject(s) - detection limit , reproducibility , threshold limit value , environmental science , relative standard deviation , occupational exposure , chromatography , personal protective equipment , confidence interval , air monitoring , mathematics , statistics , medicine , chemistry , environmental engineering , environmental health , covid-19 , disease , pathology , infectious disease (medical specialty)
Determination Method for Xylidines in Workplace Air: Akito Takeuchi, et al. Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association—Objectives The purpose of this research was to develop a determination method for xylidines (XLDs) in workplace air for risk assessment. Methods The characteristics of the proposed method, such as recovery, detection limit, reproducibility, and storage stability of the samples were examined. Results An air sampler cassette containing two sulfuric acid‐treated glass iber ilters was chosen as the sampler. The XLDs were extracted from the sampler filters, derivatized with heptafluorobutyric anhydride, and then analyzed by a gas chromatograph equipped with a mass spectrometer. The average recoveries of XLDs from the spiked sampler were 83– 101% for personal exposure monitoring. The recovery after 5 days of storage in a refrigerator exceeded 90%. The overall limit of quantitation (LOQ) was 0.600 µg/ sample. The relative standard deviation, which represents the overall reproducibility defined as precision, was 0.8–10.3%. Conclusions The proposed method enables 4‐hour personal exposure monitoring of XLDs at concentrations equaling 0.001–2 times the threshold limit value‐time‐weighted average (TLV‐TWA: 0.5 ppm) adopted by the American Conference of Governmental Industrial Hygienists, and is useful for estimating worker exposure to XLDs.