Open AccessEarly Bilateral Gonadoblastoma in a Patient with Mixed Gonadal Dysgenesis (Karyotype 45,X/46,XY): Case Report and Review of Literature
Author(s) -
Ignas Trainavičius,
Darius Dasevičius,
Birutė Burnytė,
Robertas Kemežys,
Gilvydas Verkauskas
Publication year - 2022
Publication title -
acta medica lituanica
Language(s) - English
Resource type - Journals
eISSN - 2029-4174
pISSN - 1392-0138
DOI - 10.15388/amed.2022.29.2.5
Subject(s) - gonadoblastoma , karyotype , medicine , gynecology , genetics , biology , chromosome , gene
Mixed gonadal dysgenesis is a rare congenital and challenging condition, characterized mainly by 45,X/46,XY karyotype mosaicism, asymmetrical gonadal development and various internal and external genital anatomy. Because of frequent disorder of genital development and a higher risk of germ cell neoplasia, management of these patients is complex and requires multidisciplinary approach.