Open AccessFabrication and performance of a spherical cellulose nanocrystal-based hydrophobic drug delivery vehicle using rubber wood
Author(s) -
Da Wei Zheng,
Yihui Deng,
Yue Xia,
Yiman Nan,
Meijiao Peng,
Xinduo Wang,
Jinquan Yue
Publication year - 2019
Publication title -
bioresources
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 69
ISSN - 1930-2126
DOI - 10.15376/biores.14.4.7763-7774
Subject(s) - thermogravimetric analysis , materials science , chemical engineering , cellulose , thermal stability , ammonium bromide , fourier transform infrared spectroscopy , drug delivery , drug carrier , nuclear chemistry , pulmonary surfactant , chemistry , nanotechnology , engineering
Cellulose nanocrystals (CNCs) were fabricated using rubber wood (RW) as the raw material via acid hydrolysis followed by ultrasonication. The CNCs samples were then grafted with succinic anhydride to obtain modified CNCs, hereafter called CS. The CS samples were subsequently coated with a cationic surfactant, cetyltrimethyl ammonium bromide, and the obtained samples were named as CC. The morphology, chemical structure, and thermal stability of the RW, CNCs, CS, and CC samples were characterized using transmission electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis, respectively. Finally, the drug release performance was investigated using CC as the drug carrier and hesperidin, a hydrophobic drug, as the model drug. The drug release mechanism was also considered. The results of this study identified a new route for the high-value utilization of RW and also demonstrated that RW could be used as a novel substrate for the construction of cellulose-based hydrophobic drug delivery systems.