Open AccessStem Cell Concept in Thyroid Cancer: Stem Cell
Author(s) -
Cihan Zamur,
Uğur Topal,
Harun Özdemir,
Serdar Altınay
Publication year - 2020
Publication title -
integrative journal of medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2658-8218
DOI - 10.15342/ijms.7.199
Subject(s) - cancer stem cell , thyroid cancer , stem cell , cancer , carcinogenesis , thyroid , cancer research , cancer cell , endocrine system , biology , medicine , pathology , hormone , microbiology and biotechnology
The most frequently diagnosed endocrine cancer, which causes more deaths than any other endocrine cancer, is thyroid cancer. Cancer stem cells are rare cells found in tumors that can regenerate themselves, phenotypically leads to various tumor cell populations, and trigger tumorigenesis. Cancer stem cells have been identified in many cancers, including thyroid cancer. Having an understanding of the molecular mechanisms which control the biology of cancer stem cells and the disease processes will help us in designing more rational targeted therapies for aggressive thyroid cancers. In this review, we aimed to present the currently accepted knowledge about thyroid stem cells, information regarding the cellular origin of thyroid cancer stem cells, and the clinical results of cancer stem cells present in the thyroid gland.